Science & Research

LONGENIC® enables quality of life into an advanced age full of "Beauty, Performance & Health".

For LONGENIC® we use only scientifically proven, high-quality active ingredients based on natural science in their purest form of highest bioavailability, which correspond optimally or support one another.

The formula of LONGENIC® contains Collagen (fish), Glucosamine, Chondroitin sulphate (derivative complex of Greenland shark), Nicotinamid Mononucleotid (NMN), Vitamin C and D, Resveratrol and Curcumin. The first formula to counteract the ageing process holistically and in one formula based on the latest scientific insights.

COLLAGEN

Collagen is the most abundant protein in the body. It can be found in skin, bones, tendons, organs and even teeth. Collagen is made of amino acids that are required for general health and wellness.

The rule of thumb is that collagen is important for appearance - it keeps our skin firm, healthy and youthful. The natural production of this protein slows down as we age, which leads to aging on our skin. Clinical research has shown that collagen supplements can help us reverse some of the signs of aging- they are essential for anti-aging.

STUDIES
1. Schlippe et al., Akt. Dermatol. 2015.
2. Kerscher et al., IMCAS World Congress 2018.
3. Bolke et al., 9th Intern. Conference on Skin Ageing & Challenges 2018.
RESVERATROL

Resveratrol is a potent activator of Sirtuin enzymes found in the mitochondria. Resveratrol is a naturally occurring polyphenolic compound found in plants, particularly grapes, peanuts, and some types of blueberries. The word "resveratrol" is derived from Latin, meaning "to ward off old age". Resveratrol has been shown to activate several targets involved in longevity, including sirtuins, enzymes that act on cellular DNA and regulate mitochondria function, protect against age-related hearing loss, increase tolerance to stress and reduce oxidative stress.

STUDIES
1. Turner RS, Thomas RG, Craft S, Van Dyck et. al. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease
2. Sawda C, Moussa C, Turner RS. Resveratrol for Alzheimer's disease
3. Moussa C, Hebron M, Huang X, Ahn J, Rissman RA, Aisen PS, Turner RS. Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease
Glucosamine & Chondroitin

If you suffer with arthritis, you may not be able to live your life as you would like. The pain is one of the most common symptoms of arthritis, usually found in the joints or muscles.

There are three different types of arthritis: Chronic conditions like rheumatoid arthritis, osteoarthritis, and gout are all very common and can cause serious pain. Glucosamine and Chondroitin are often taken together to help relieve the symptoms of arthritis. They work by reducing inflammation, which is the main cause of pain in people with osteoarthritis. Non-steroidal anti-inflammatory drugs (NSAIDs) are used to manage joint pain and inflammation associated with these autoimmune diseases.

STUDIES
1. https://ter-arkhiv.ru/0040-3660/article/view/60259
2. https://www.sciencedirect.com/science/article/pii/S1063458498800113
3. https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/215809
Nicotinamid Mononucleotid (NMN)

Scientists have discovered in published studies that a natural compound called Nicotinamide Mononucleotide (NMN) can reverse many aspects of aging.

Nicotinamide mononucleotide, NMN, is a molecule that has been identified as a key factor in reversing the effects of ageing in mouse stem cells. The NMN molecule increases NAD+, which is linked to human metabolism and cellular energy. The researchers found that by supplementing mice with NMN, they were able to reverse some of the effects of cell ageing observed in these mice.

After six weeks, the researchers noted increased blood vessel numbers and improved mitochondrial function in both liver and muscle tissue and found that it may be possible to rebuild muscle mass. Improve cognitive function and increase endurance. It is used to treat angiogenesis (growth of new blood vessels), ischaemia (lack of blood flow) and heart damage caused by exercise.

STUDIES
1. Schlippe et al., Akt. Dermatol. 2015
2. Kerscher et al., IMCAS World Congress 2018.
3. Bolke et al., 9th Intern. Conference on Skin Ageing & Challenges 2018.
CURCUMIN

Curcumin is a polyphenol with potent antioxidant and anti-inflammatory effects. It can be used for the treatment of cardiovascular diseases.

Curcumin has been extensively studied for its anti-inflammatory and antioxidant properties. It has been shown to reduce low-density lipoprotein (LDL) oxidation and platelet aggregation, inhibit blood clotting, stimulate production of nitric oxide (NO), inhibit the expression of proinflammatory cytokines such as TNF α and IL-1β, ihibit expression of inflammatory enzymes such as cyclooxygenase (COX) and lipoxygenase, and scavenge reactive oxygen species. Studies have proven that it can also be beneficial to the treatment of depression and Alzheimer's disease.

STUDIES
1. Braun L, Cohen M. Herbs and Natural Supplements: An Evidence-Based Guide: Volume 2.
2. Australia, Churchill Livingstone
3. Wongcharoen W, Phrommintikul A. The Protective Role of Curcumin in Cardiovascular Diseases
4. Rivera-Espinoza Y, Muriel P. Pharmacological Actions of Curcumin in Liver Diseases or Damage
5. Kuo JJ, et al. Positive Effect of Curcumin on Inflammation and Mitochondrial Dysfunction in Obese Mice with Liver Steatosis
LONGENIC® improves significantly total skin extensibility.

The perception of the volunteers about how LONGENIC® performs was a main component of the clinical study. All the women completed self-assessment questionnaires at the onset of the trial and at the end of the study. LONGENIC® versus placebo may reduce significantly the wrinkles, P < 0.05.

Cutometer® SEM 575 by COURAGE & KHAZAKA was used to measure a deformation perpendicular to the skin for 2 seconds, followed by a relaxation period of 2 seconds. This method measures the degree of deformation and the time required for the skin to return to its original state. The deformation induced on the skin is measured by an optical system. The measured parameters are: Ue, the elastic deformation; Ur, the elastic back deformation; Uf the total extensibility of the skin; Ua, the total deformation recovery; Ur/Ue the pure elasticity

Skin Hydration

This device measures the electrical capacitance of the skin which is expressed as an index of hydration. It allows to assess the hydration state of the first layers using electrical capacitance measurements.

LONGENIC® improves significantly skin hydration after 6 and 12 weeks.